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The rat cytomegalovirusencoded protein E27 induces proteasomal STAT2 degradation E27 binds and exploits DDB1containing Cullin4RING ubiquitin ligases (CRL4) by mimicking endogenous CRL4 substrate receptors, DCAFs CryoEM shows that E27 recruits STAT2 via a bipartite interface, positioning STAT2 for CRL4catalysed ubiquitylation The homologous mouse cytomegalovirus factor M27 establishes interferon resistance in mouse models via CRL4mediated STAT2 degradation Similar content being viewed by others Introduction Human cytomegalovirus (HCMV

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